Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma.
David A KaminskyDavid G ChapmanJanet T HolbrookRobert J HendersonElizabeth A SugarJohn MastronardeWilliam G TeagueMichael BuskKaharu SuminoAnne E DixonRobert A WiseCharles G IrvinPublished in: Respirology (Carlton, Vic.) (2019)
Our findings confirm that airway closure in response to methacholine occurs in a large, diverse population of asthmatic participants, and that increased airway closure is associated with older age and obesity. These findings suggest that therapies targeting airway closure may be important in patients with a high closing index.