Studying additive interaction in a healthcare database: Case study of NSAIDs, cardiovascular profiles, and acute myocardial infarction.
Michèle BallyLyne NadeauJames M BrophyPublished in: PloS one (2018)
Alternative specifications of NSAID exposure concurred in finding that concomitant use of cardioprotective aspirin does not attenuate the risks of acute MI with NSAIDs. However we were unable to demonstrate consistent interactions between an individual's cardiovascular comorbidities and NSAID-associated acute MI. Our study highlights challenges of studying additive interactions in a healthcare database and underscores the need for sensitivity analyses.
Keyphrases
- healthcare
- liver failure
- acute myocardial infarction
- respiratory failure
- anti inflammatory drugs
- drug induced
- aortic dissection
- low dose
- adverse drug
- percutaneous coronary intervention
- hepatitis b virus
- cardiovascular events
- left ventricular
- human health
- heart failure
- type diabetes
- emergency department
- intensive care unit
- health insurance
- social media
- mechanical ventilation
- electronic health record
- acute respiratory distress syndrome