Adjusted vascular contractility relies on integrity of progranulin pathway: Insights into mitochondrial function.
Shubhnita SinghAriane Bruder-NascimentoRafael M CostaJuliano Vilela AlvesSivakama BharathiEric S GoetzmanThiago Bruder-NascimentoPublished in: bioRxiv : the preprint server for biology (2023)
Our findings suggest that PGRN preserves the vascular contractility via regulating mitophagy flux, mitochondrial complex I activity, and redox signaling. Therefore, loss of PGRN function appears as a pivotal risk factor in CVD development.