Familial Male-limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors.
Cezanne D KooijAnnelies M C Mavinkurve-GroothuisIdske C L Kremer HovingaLeendert H J LooijengaTuula RinneJacques C GiltayLaetitia M O de KortAart J KlijnRonald R de KrijgerAnnemarie A Verrijn StuartPublished in: The Journal of clinical endocrinology and metabolism (2022)
There is a strong suggestion that FMPP might increase the risk of development of testicular GCTs in early adulthood compared with the risk in the general population. Therefore, prolonged patient monitoring from mid-pubertal age onward including instruction for self-examination and periodic testicular ultrasound investigation in patients with a germline LHCGR pathogenic variant might contribute to early detection and thus early treatment of testicular GCT.