The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease.

Milan ZimmermannLeonie KöhlerMarketa KovarovaStefanie LercheClaudia SchulteIsabel WursterGerrit MachetanzChristian DeuschleAnn-Kathrin HauserThomas GasserDaniela BergErwin SchleicherWalter MaetzlerKathrin Brockmann

Published in: European journal of neurology (2021)

Our results indicate that genetic variants in Klotho together with its corresponding CSF protein profiles are associated with aspects of disease severity in PD. These findings suggest that pathways associated with aging might be targets for future biomarker research in PD.

Keyphrases

cerebrospinal fluid
protein protein
binding protein
current status
copy number
small molecule
transcription factor
genome wide identification