Diabetes duration and obesity matter in autologous mesenchymal stem/stromal cell transplantation in type 2 diabetes patients.
Joonyub LeeKun-Ho YoonPublished in: Journal of diabetes investigation (2021)
Type 2 diabetes develops due to functional β cell loss after insulin resistance. Sustained increased insulin demand compels β cells into apoptosis and dedifferentiation resulting in decreased β cell mass. In adult humans, β cell regeneration (proliferation, neogenesis or transdifferentiation) rarely occurs in a physiologic condition. Because of this stagnant nature of β cells, β cell mass are not sufficiently recovered once their numbers are severely decreased. Constant efforts have been made to replenish the decreased β cell mass in diabetic patients by islet or pancreas transplantation1,2 .
Keyphrases
- type diabetes
- cell therapy
- insulin resistance
- single cell
- stem cells
- induced apoptosis
- glycemic control
- bone marrow
- cardiovascular disease
- chronic kidney disease
- end stage renal disease
- oxidative stress
- adipose tissue
- endoplasmic reticulum stress
- cell proliferation
- ejection fraction
- pi k akt
- weight gain
- high fat diet induced
- platelet rich plasma
- quality improvement