A cerebellar degeneration related protein 2-like cell-based assay for anti-Yo detection in patients with paraneoplastic cerebellar degeneration.

The CDR2L CBA is highly reliable for identification of Yo-PCD. Although our findings indicate that currently the combination of CDR2 and CDR2L yields the most reliable test results, it remains to be evaluated if a test for single anti-CDR2L positivity will serve as a sufficient biomarker for Yo-PCD diagnosis.