Pulmonary Arterial Hypertension Patients Have a Proinflammatory Gut Microbiome and Altered Circulating Microbial Metabolites.

Daphne M MoutsoglouJasmine TatahSasha Z PriscoKurt W PrinsChristopher StaleySharon LopezMadelyn BlakeLevi TeigenFelipe KazmirczakE Kenneth WeirAmanda J KabageWeihua GuanAlexander KhorutsThenappan Thenappan

Published in: American journal of respiratory and critical care medicine (2022)

PAH patients have proinflammatory gut dysbiosis in which lower circulating SCFAs and secondary bile acids may facilitate pulmonary vascular disease. These findings support investigating modulation of the gut microbiome as a potential treatment for PAH.

Keyphrases

pulmonary arterial hypertension
end stage renal disease
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
pulmonary artery
risk assessment
ms ms
climate change
replacement therapy