Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.

Yaiza M ArenasAdrià López-GramajeCarmina MontoliuMarta LlansolaVicente Felipo

Published in: Biological research (2024)

All these steps are triggered by enhanced activation of IL-17 receptor in microglia and are prevented by ex-vivo treatment with anti-IL-17. IL-17 and IL-17 receptor in microglia would be therapeutic targets to treat neurological impairment in patients with MHE.

Keyphrases

inflammatory response
neuropathic pain
spinal cord injury
lipopolysaccharide induced
binding protein
lps induced
combination therapy