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Transcriptional dynamics of transposable elements when converting fibroblast cells of Macaca mulatta to neuroepithelial stem cells.

Dahai LiuLi LiuKui DuanJunqiang GuoShipeng LiZhigang ZhaoXiaotuo ZhangNan ZhouYun Zheng
Published in: BMC genomics (2021)
These results suggest that the transcription of TEs are delicately regulated during the reprogramming of Macaca mulatta fibroblast cells. Although the family of ERVs activated during the reprogramming of fibroblast cells in Macaca mulatta is different from those in the reprogramming of human fibroblast cells, our results suggest that the activation of some ERVs is a conserved mechanism in primates for converting fibroblast cells to stem cells.
Keyphrases
  • induced apoptosis
  • stem cells
  • cell cycle arrest
  • transcription factor
  • endoplasmic reticulum stress
  • gene expression
  • oxidative stress
  • bone marrow
  • cell proliferation
  • induced pluripotent stem cells