Cerebral Small Vessel Disease Progression Increases Risk of Incident Parkinsonism.
Mina A JacobMengfei CaiMayra BergkampSirwan K L DarweeshLiza M Y GelissenJosé MarquesDavid G NorrisMarco DueringRianne A J EsselinkAnil M TuladharFrank-Erik de LeeuwPublished in: Annals of neurology (2023)
Both baseline SVD severity and SVD progression are independently associated with long-term parkinsonism. Our findings indicate a causal role of SVD in parkinsonism. Future studies are needed to examine the underlying pathophysiology of this relation. ANN NEUROL 2023.