Evaluation of Response to High-Dose Intravenous Vitamin K Administration.
April R ChapmanJason R YerkeMollie LumpkinMichael A RudoniMichael MilitelloLu WangStephanie N BassPublished in: The Annals of pharmacotherapy (2023)
In this study of mainly patients with cirrhosis, the overall adjusted decrease in INR over 3 days was 0.3, which may have minimal clinical impact. Additional studies are needed to identify populations who may benefit from repeated daily doses of high-dose IV vitamin K.