Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit.
Reuth NirFrancesca SperottoManasee GodsayMinmin LuJohn J KheirPublished in: Paediatric drugs (2023)
While in patients ventilated < 5 days opioids initially increased and then quickly decreased in the 72 h following DEX initiation, among patients ventilated ≥ 5 days opioids doubled, then decreased only minimally; benzodiazepines decreased minimally in both groups, although more slowly in the long-ventilation cohort. These findings may inform decision-making on timing of DEX initiation in ventilated patients already being treated with opioid or benzodiazepine infusions.
Keyphrases
- intensive care unit
- end stage renal disease
- chronic pain
- pain management
- newly diagnosed
- acute respiratory distress syndrome
- chronic kidney disease
- ejection fraction
- mechanical ventilation
- peritoneal dialysis
- prognostic factors
- heart failure
- low dose
- left ventricular
- extracorporeal membrane oxygenation
- cardiac surgery