Photothrombosis induced cortical stroke produces electrographic epileptic biomarkers in mice.

Dana C Shaw Krishnakanth KondaboluKatherine G WalshWen ShiEnrico RillosiMaxine HsiungUri T Eden Robert Mark Richardson Mark A Kramer Catherine J ChuXue Han

Published in: bioRxiv : the preprint server for biology (2024)

Cortical photothrombosis in mice produces stroke with characteristic intermittent focal delta slowing.Cortical photothrombosis stroke in mice produces the epileptic biomarkers spikes, ripples, and spike ripples.All biomarkers share morphological features with the corresponding human correlate.Spike ripples better lateralize to the lesional cortex than spikes or ripples.This cortical model can be applied in transgenic mice for mechanistic studies.

Keyphrases

atrial fibrillation
high fat diet induced
endothelial cells
high glucose
high intensity
cerebral ischemia
adipose tissue
subarachnoid hemorrhage