Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.
Tomáš MacháčekClaudia D FuchsFranziska WinkelmannMarcus FrankHubert ScharnaglTatjana StojakovicMartina SombetzkiMichael TraunerPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
The loss of Bsep and the resulting changes in bile acid composition and blood pH are associated with the reduction of parasite fecundity, thus attenuating the development of S. mansoni-induced hepatic inflammation and fibrosis.