TNFR1 Absence Is Not Crucial for Different Types of Cell Reaction to TNF: A Study of the TNFR1-Knockout Cell Model.
Alina A AlshevskayaJulia A LopatnikovaJulia V ZhukovaOlga Y Perik-ZavodskaiaSaleh AlrhmounIrina A ObleukhovaAnna K MatveevaDarya A SavenkovaIlnaz R ImatdinovDmitry V YudkinSergey V SennikovPublished in: Epigenomes (2024)
The absence of TNFR1 leads to different variants of compensatory redistribution of TNFR2 in cellular models, which affects the type of cell response and the threshold level of sensitivity. The directionality of cytokine action modulation and sensitivity to TNF levels depends not only on the fraction of cells expressing TNFR2 but also on the density of expression.