Body Fat Distribution and Risk of Breast, Endometrial, and Ovarian Cancer: A Two-Sample Mendelian Randomization Study.

Dennis Freuer Jakob Linseisen Tracy A O'MaraMichael LeitzmannHansjoerg Baurecht Sebastian-Edgar BaumeisterChrista Meisinger

Published in: Cancers (2021)

Visceral adiposity seems to be a driver of elevated ovarian cancer risk, particularly of the endometrioid and clear cell ovarian cancer histotypes. General adiposity decreases the risk of breast cancer but increases the risk of endometrial and ovarian cancer.

Keyphrases

clear cell
insulin resistance
endometrial cancer
weight gain
adipose tissue
skeletal muscle