Immunohistochemical and Molecular Characterization of Endometrial Stromal Sarcomas.

Sneha Subbaraya Sudha S MurthySandhya Devi G

Published in: Clinical pathology (Thousand Oaks, Ventura County, Calif.) (2020)

Endometrial stromal sarcomas are rare tumours (1.8% in this study). JAZF1-SUZ12 and YWHAE-FAM22 gene rearrangement helps in accurate characterization of ESS and can be used as diagnostic tools especially when the diagnosis is unclear or difficult. Cyclin D1 can be used as an adjuvant immunomarker for YWHAE gene-rearranged HG-ESS.

Keyphrases

bone marrow
copy number
genome wide
high grade
endometrial cancer
early stage
genome wide identification
cell cycle
high resolution
dna methylation
cell proliferation
transcription factor
signaling pathway