Titin-Truncating variants Predispose to Dilated Cardiomyopathy in Diverse Populations.

John DePaoloMarc BornsteinRenae JudySarah AbramowitzShefali S VermaMichael G LevinZoltan AranyScott M Damrauer

Published in: medRxiv : the preprint server for health sciences (2024)

TTNtvs are associated with increased risk of DCM among a diverse cohort. There is no significant difference in effect of TTNtvs on DCM risk across deciles of GD from the 1000G European centroid, suggesting genetic background should not be considered when screening individuals for titin-related DCM.

Keyphrases

copy number
drug induced