This review discusses the possible involvement of infections-associated cancers in humans, with virus infections contributing 15% to 20% of total cancer cases in humans. DNA virus encoded proteins interact with host cellular signaling pathways and control proliferation, cell death and genomic integrity viral oncoproteins are known to bind cellular Deubiquitinates (DUBs) such as cyclindromatosis tumor suppressor, ubiquitin-specific proteases 7, 11, 15 and 20, and A-20 to improve their intracellular stability and cellular signaling pathways and finally transformation. Human papillomaviruses (cervical carcinoma, oral cancer and laryngeal cancer); human polyomaviruses (mesotheliomas, brain tumors); Epstein-Barr virus (B-cell lymphoproliferative diseases and nasopharyngeal carcinoma); Kaposi's Sarcoma Herpesvirus (Kaposi's Sarcoma and primary effusion lymphomas); hepatitis B (hepatocellular carcinoma (HCC)) cause up to 20% of malignancies around the world.
Keyphrases
- epstein barr virus
- endothelial cells
- papillary thyroid
- signaling pathway
- cell death
- squamous cell
- induced pluripotent stem cells
- diffuse large b cell lymphoma
- sars cov
- circulating tumor
- single molecule
- gene expression
- squamous cell carcinoma
- childhood cancer
- dna methylation
- cell free
- pi k akt
- young adults
- epithelial mesenchymal transition
- lymph node metastasis
- cell proliferation
- reactive oxygen species
- oxidative stress
- copy number
- induced apoptosis
- nucleic acid
- genome wide