Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions.
Yu FangAngelina Olegovna ZekiyFarhoodeh GhaedrahmatiAnton TimoshinMaryam FarzanehAmir AnbiyaieeSeyed Esmaeil KhoshnamPublished in: Cell communication and signaling : CCS (2021)
The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a scaffold or adaptor in various physiological and pathological processes. Trib2 can interact with E3 ubiquitin ligases and control protein stability of downstream effectors. This protein is induced by mitogens and enhances the propagation of several cancer cells, including myeloid leukemia, liver, lung, skin, bone, brain, and pancreatic. Thus, Trib2 can be a predictive and valuable biomarker for the diagnosis and treatment of cancer. Recent studies have illustrated that Trib2 plays a major role in cell fate determination of stem cells. Stem cells have the capacity to self-renew and differentiate into specific cell types. Stem cells are important sources for cell-based regenerative medicine and drug screening. Trib2 has been found to increase the self-renewal ability of embryonic stem cells, the reprogramming efficiency of somatic cells, and chondrogenesis. In this review, we will focus on the recent advances of Trib2 function in tumorigenesis and stem cell fate decisions. Video abstract.
Keyphrases
- cell fate
- stem cells
- protein kinase
- cell therapy
- embryonic stem cells
- single cell
- induced apoptosis
- bone marrow
- signaling pathway
- acute myeloid leukemia
- soft tissue
- gene expression
- binding protein
- squamous cell carcinoma
- papillary thyroid
- dendritic cells
- amino acid
- cell cycle arrest
- cell proliferation
- bone mineral density
- tyrosine kinase
- molecularly imprinted