Genotyping NUDT15*3 rs1166855232 reveals higher frequency of potential adverse effects of thiopurines in Natives and Mestizos from Mexico.

Tomas TexisCintia Guzmán-CruzMauricio Rodríguez-DorantesSergio Sánchez-GarcíaDolores Mino-LeónVanessa González-Covarrubias

Published in: Pharmacological reports : PR (2021)

TPMT*3B and NUDT15 rs116855232 actionable markers showed population differences that ought to be considered as dosing inferences highlight the relevance of routine genotyping of these variants for the prescription of thiopurines in Mexican populations.

Keyphrases

genetic diversity
genome wide
high throughput
copy number
clinical practice
dna methylation
human health
risk assessment
climate change