A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration.
Lakshmi KuttippurathuEgle JuskeviciuteRachael P DippoldJan B HoekRajanikanth VadigepalliPublished in: BMC genomics (2016)
Our novel comparative pattern analysis revealed new insights into ethanol-mediated molecular changes in non-parenchymal liver cells as a possible contribution to the defective liver regeneration phenotype. The results revealed for the first time an ethanol-induced shift of hepatic stellate cells from a pro-regenerative phenotype to that of an anti-regenerative state after PHx. Our results can form the basis for novel interventions targeting the non-parenchymal cells in normalizing the dysfunctional repair response process in alcoholic liver disease. Our approach is illustrated online at http://compact.jefferson.edu .
Keyphrases
- stem cells
- induced apoptosis
- cell cycle arrest
- single cell
- mesenchymal stem cells
- cell therapy
- physical activity
- social media
- endoplasmic reticulum stress
- cell death
- signaling pathway
- rna seq
- bone marrow
- gene expression
- tissue engineering
- drug induced
- endothelial cells
- alcohol consumption
- high glucose
- single molecule
- diabetic rats
- low cost