Valproate serum concentrations in patients with hypoalbuminemia and medical complications.

Amy M VandenBerg Jessica Broadway Callie Lalich Rachel Kennedy Kristen Mullinax

Published in: The mental health clinician (2018)

Due to the variability in pharmacokinetic impact of hypoalbuminemia, it is important to monitor patients closely for signs of VPA toxicity in cases involving altered albumin levels. It would be prudent to use free serum VPA concentrations when patients experience fluctuations in albumin or have unexpected response to medication.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
emergency department
risk factors
drug induced