Valproate serum concentrations in patients with hypoalbuminemia and medical complications.
Amy M VandenBergJessica BroadwayCallie LalichRachel KennedyKristen MullinaxPublished in: The mental health clinician (2018)
Due to the variability in pharmacokinetic impact of hypoalbuminemia, it is important to monitor patients closely for signs of VPA toxicity in cases involving altered albumin levels. It would be prudent to use free serum VPA concentrations when patients experience fluctuations in albumin or have unexpected response to medication.