Risks of genetic damage in offspring conceived using spermatozoa produced during chemotherapy or radiotherapy.
Marvin L MeistrichPublished in: Andrology (2020)
A schema showing the time from initiation of therapy at which specific antineoplastic agents can cause significant levels of genetic damage in conceptuses and live offspring was developed. The estimates and methods for computing the level of such risk from an individual patient's treatment regimen will enable patients and counselors to make informed decisions on the use of spermatozoa or continuation of a pregnancy.
Keyphrases
- end stage renal disease
- oxidative stress
- high fat diet
- genome wide
- locally advanced
- ejection fraction
- newly diagnosed
- chronic kidney disease
- radiation therapy
- peritoneal dialysis
- copy number
- squamous cell carcinoma
- type diabetes
- case report
- pregnant women
- gene expression
- metabolic syndrome
- rectal cancer
- radiation induced
- human health
- climate change
- cell therapy