Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies.
Salvatore SciacchitanoClaudia De VitisMichela D'AscanioSimonetta GiovagnoliChiara De DominicisAndrea LaghiPaolo AnibaldiAndrea PetruccaGerardo SalernoIolanda SantinoRachele AmodeoMaurizio SimmacoChristian NapoliAgostino TafuriArianna Di NapoliAndrea SacconiValentina SalvatiGennaro CilibertoMaurizio FanciulliGiulia PiaggioLuisa de LatouliereAlberto RicciRita ManciniPublished in: Journal of translational medicine (2021)
Our study demonstrates that low FT3 serum levels are associated with severe COVID-19. Our multi-omics approach suggests that T3 is involved in the immune response in COVID-19 and coexistent hematological malignancy and new possible T3 target genes in these patients have been identified.
Keyphrases
- single cell
- sars cov
- coronavirus disease
- immune response
- end stage renal disease
- rna seq
- newly diagnosed
- ejection fraction
- genome wide
- chronic kidney disease
- case report
- high throughput
- prognostic factors
- peritoneal dialysis
- genome wide identification
- early onset
- dendritic cells
- transcription factor
- dna methylation
- inflammatory response
- genome wide analysis
- data analysis
- bioinformatics analysis