Distinct Features of Plasma Ultrashort Single-Stranded Cell-Free DNA as Biomarkers for Lung Cancer Detection.
Jordan C ChengNeeti SwarupFeng LiMisagh KordiChien-Chung LinSzu-Chun YangWei-Lun HuangMohammad AzizYong KimDavid ChiaYu-Min YehFang WeiDavid ZhengZarina YelskayaMatteo PellegriniWu-Chou SuDavid T W WongPublished in: Clinical chemistry (2023)
These observations indicate that the distinct biological processes of uscfDNA and that FE peaks, fragmentomics, end-motifs, and G-Quad signatures are uscfDNA features with promising biomarker potential. These findings further justify its exploration as a distinct class of biomarker to augment pre-existing liquid biopsy approaches.