A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer.
Matthew B SchabathTapashi B DalviHongyue A DaiAlan L CrimAnita MidhaNorah ShireNicholas T GimbroneJill WalkerDanielle M GreenawaltDavid LawrenceJames R RigasRobert BrodyDanielle PotterNaveen S KumarShane A HuntsmanJhanelle E GrayPublished in: Cancer management and research (2019)
In this retrospective analysis, survival outcomes of patients with advanced NSCLC were comparable by PD-L1 expression level. EGFR and KRAS mutation status were not found to be significantly associated with PD-L1 expression level, while TMB was weakly associated with PD-L1 expression level. Overall, PD-L1 expression level was not observed to be an independent prognostic biomarker in this cohort of patients with advanced NSCLC treated with chemotherapy.
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