Affective temperaments (TEMPS-A) in panic disorder and healthy probands: Genetic modulation by 5-HTT variation.

Miriam A SchieleKatharina HerzogLeonie KollertJoscha BöhnleinJonathan ReppleKaroline RosenkranzElisabeth J LeehrChristiane ZieglerUlrike LuekenUdo DannlowskiPaul PauliVolker AroltPeter ZwanzgerJürgen DeckertAndreas ErfurthKatharina Domschke

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2020)

Dysthymic, cyclothymic, irritable and notably anxious temperament could serve as valuable intermediate phenotypes in efforts to unravel neurobiological, particularly serotonin system related genetic pathomechanisms associated with PD and potentially contribute to a panel of vulnerability markers guiding early targeted preventive interventions.

Keyphrases

genome wide
copy number
climate change
physical activity
bipolar disorder
cancer therapy
quality improvement
dna methylation