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Brain plasticity and neuroinflammatory protein biomarkers with circulating MicroRNAs as predictors of acute brain injury outcome - A prospective cohort study.

Antti SajantiYan LiSanttu HellströmYing CaoRomuald GirardJuzoh UmemoriJanek FrantzénFredrika KoskimäkiSeán B LyneJohannes FalterTomi RantamäkiRiikka TakalaJussi P PostiSusanna RoineSulo KolehmainenAbhinav SrinathMiro JänkäläJukka PuolitaivalMelissa RahiJaakko RinneEero CastrénJanne Koskimäki
Published in: Journal of the neurological sciences (2024)
The combined prognostic microRNA and protein biomarker models demonstrated accurate outcome prognostication across diverse injury types, implying the presence of a common recovery mechanism. DE microRNAs were found to target the studied molecules, suggesting a potential mechanistic role in recovery. Further investigation is warranted to study these molecules in prognostication, as well as therapeutic targets for enhancing recovery.
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