Association of Acute Increases in Plasma Creatinine after Renin-Angiotensin Blockade with Subsequent Outcomes.
Edouard L FuMarco TrevisanCatherine M ClaseMarie EvansBengt LindholmJoris I RotmansMerel van DiepenFriedo W DekkerJuan-Jesus CarreroPublished in: Clinical journal of the American Society of Nephrology : CJASN (2019)
Among real-world monitored adults, increases in creatinine (>10%) after initiation of RASi are associated with worse health outcomes. These results do not address the issue of discontinuation of RASi when plasma creatinine increases but do suggest that patients with increases in creatinine have higher subsequent risk of cardiovascular and kidney outcomes.