Microsatellite instability at U2AF-binding polypyrimidic tract sites perturbs alternative splicing during colorectal cancer initiation.
Vincent JonchèreHugo MontémontEnora Le ScanfAurélie SiretQuentin LetourneurEmmanuel TubacherChristophe BattailAssane FallKarim LabrecheVictor RenaultToky RatovomananaOlivier BuhardAriane JollyPhilippe Le RouzicCody FeysEmmanuelle DesprasHabib ZoualiRémy NicollePascale CerveraMagali SvrcekPierre BourgoinHélène BlanchéAnne BolandJérémie LefèvreYann ParcMehdi TouatFranck BielleDanielle ArzurGwennina CueffCatherine Le Jossic-CorcosGaël QuéréGwendal DujardinMarc BlondelCédric Le MaréchalRomain CohenThierry AndréFlorence CouletPierre de la GrangeAurélien de ReynièsJean-François FléjouFlorence RenaudAgusti AlentornLaurent CorcosJean-François DeleuzeAda ColluraAlex DuvalPublished in: Genome biology (2024)
Overall, these findings provide evidence that a very early RNA splicing signature partly driven by MSI impairs cell differentiation and promotes MSI CRC initiation, far before coding mutations which accumulate later during MSI tumorigenesis.