Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection.
Stacey A LappVenkata-Viswanadh EdaraAustin LuLilin LaiLaila HussainiAnn ChahroudiLarry J AndersonMehul S SutharEvan J AndersonChristina A RostadPublished in: PloS one (2021)
Prior murine exposure to HKU1 spike protein completely impeded the development of neutralizing antibodies to SARS-CoV-2, consistent with original antigenic sin. In contrast, the presence of HKU1 spike IgG antibodies in children with acute COVID-19 or MIS-C was not associated with diminished neutralizing antibody responses to SARS-CoV-2.