Relationship Between Maximal Left Ventricular Wall Thickness and Sudden Cardiac Death in Childhood Onset Hypertrophic Cardiomyopathy.
Gabrielle NorrishTao DingElla FieldElena CerviLidia ZiółkowskaIacopo OlivottoDiala KhraicheGiuseppe LimongelliAris AnastasakisRobert G WeintraubElena BiaginiLuca RagniTerence W PrendivilleSophie DuignanKaren McLeodMaria IlinaAdrián FernándezChiara MarroneRegina BökenkampAnwar BabanPeter KubusPiers E F DaubeneyGeorgia Sarquella BrugadaSergi CésarSabine KlaassenTiina H OjalaVinay BholeConstancio MedranoOrhan UzunElspeth BrownFerran GranGianfranco SinagraFrancisco J CastroA Graham StuartGabriele VignatiHirokuni YamazawaRoberto Barriales VillaLuis García-GueretaSatish AdwaniKatie LinterTara BharuchaPablo Garcia-PaviaAna SilesTorsten B RasmussenMargherita CalcagninoCaroline B JonesHans De WildeToru KuboTiziana FeliceAnca PopoiuJens MogensenSujeev MathurFernando CentenoZdenka ReinhardtSylvie SchouveyCostas O'MahonyRumana Z OmarPerry Mark ElliottJuan Pablo Pablo KaskiPublished in: Circulation. Arrhythmia and electrophysiology (2022)
In children with HCM, an inverted U-shaped relationship exists between left ventricular hypertrophy and estimated SCD risk. The presence of additional risk factors has a summative effect on risk. While MLVWT is important for risk stratification, it should not be used either as a binary variable or in isolation to guide implantable cardioverter defibrillator implantation decisions in children with HCM.