Structure-function coupling reveals the brain hierarchical structure dysfunction in Alzheimer's disease: A multicenter study.

Yibao SunPan WangKun ZhaoPindong ChenYida QuZhuangzhuang LiSuyu ZhongBo ZhouJie LuXi ZhangDawei WangYing HanHongxiang YaoYong Liu

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

This study utilized multi-center, multi-modal data from East Asian populations. We found an increased spatial gradient of the structure decoupling index (SDI) from sensory-motor to higher-order cognitive regions. Changes in SDI are associated with energy metabolism and mitochondria. SDI can identify Alzheimer's disease (AD) and further uncover the disease mechanisms of AD.

Keyphrases

cognitive decline
big data
deep learning
mild cognitive impairment
ionic liquid
functional connectivity