Recent Advances in Cancer Immunotherapy with a Focus on FDA-Approved Vaccines and Neoantigen-Based Vaccines.
Anna HargraveAbu Salim MustafaAsma HanifJaved H TunioShumaila Nida M HanifPublished in: Vaccines (2023)
Cancer immunotherapies refer to the concept of retraining the immune system to target malignant cells. Multiple immunotherapeutic options exist including immune modulating antibodies, immune stimulating cytokines, chimeric antigen receptor T cell therapy, and vaccines. Overall, this field has advanced rapidly as knowledge of the tumor microenvironment, immunological pathways, and biotechnology expands. Specifically, advancements in neoantigen identification, characterization, and formulation into a vaccine show promise. This review is focused on previously United States Food and Drug Administration-approved cancer therapeutic vaccines and neoantigen-based vaccine developments along with the associated relevant clinical trials.
Keyphrases
- drug administration
- cell therapy
- papillary thyroid
- clinical trial
- induced apoptosis
- squamous cell
- healthcare
- drug delivery
- squamous cell carcinoma
- big data
- childhood cancer
- machine learning
- cell cycle arrest
- oxidative stress
- cell proliferation
- endoplasmic reticulum stress
- cell death
- artificial intelligence
- bone marrow
- study protocol
- bioinformatics analysis