Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction.
Julia NovotnyPaul OberdieckAnna TitovaJaroslav PelisekSue ChandraratnePhilipp NicolAlexander HapfelmeierMichael JonerLars MaegdefesselHolger PoppertJoachim PircherSteffen MassbergBenjamin FriedrichClaus ZimmerChristian SchulzTobias Boeckh-BehrensPublished in: Neurology (2020)
In our detailed histologic analysis of arterial thrombi, thrombus composition and especially abundance of leukocyte subsets differed between patients with AIS and AMI. The presence and amount of NETs were associated with patients' outcome after AIS and AMI, supporting a critical impact of NETs on thrombus stability in both conditions.
Keyphrases
- end stage renal disease
- acute myocardial infarction
- ejection fraction
- newly diagnosed
- atrial fibrillation
- chronic kidney disease
- prognostic factors
- peripheral blood
- peritoneal dialysis
- left ventricular
- coronary artery disease
- percutaneous coronary intervention
- antibiotic resistance genes
- microbial community
- anaerobic digestion