Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells.
Ajda Çoker GürkanEsin CanSemanur SahinPinar Obakan YerlikayaElif-Damla ArisanPublished in: Molecular biology reports (2021)
Atiprimod induced prolonged ER stress-mediated apoptosis via both activating PERK/eIF2α/ATF4/CHOP axis and suppressing STAT3/NF-κB transcription factors nuclear migration in TBNC cells.
Keyphrases
- cell cycle arrest
- cell death
- signaling pathway
- endoplasmic reticulum stress
- breast cancer cells
- induced apoptosis
- pi k akt
- transcription factor
- diffuse large b cell lymphoma
- cell proliferation
- lps induced
- high glucose
- oxidative stress
- diabetic rats
- endoplasmic reticulum
- nuclear factor
- drug induced
- endothelial cells
- immune response
- genome wide identification