DNA methylation profile in patients with indolent systemic mastocytosis.

Aleksandra GórskaEwa JabłońskaEdyta ReszkaMarek NiedoszytkoMagdalena LangeMarta Gruchała-NiedoszytkoJustyna JarczakDominik StrapagielMagdalena Górska-PonikowskaPaulina BastianIwona Pelikant-MałeckaLeszek KalinowskiBogusław Nedoszytko

Published in: Clinical and translational allergy (2021)

Decreased DNA demethylation in the blood DNA of patients with ISM confirms that epigenetic alterations are involved in mastocytosis pathology. We observed a possible role of allergy as an important epigenetic modifier. There is a possible association between KIT mutations and the methylation status observed in human mast cell lines.

Keyphrases

dna methylation
circulating tumor
genome wide
gene expression
cell free
single molecule
endothelial cells
nucleic acid
induced pluripotent stem cells
copy number
circulating tumor cells
atopic dermatitis
hodgkin lymphoma
drug induced