Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney.

Frank Y MaYingjie HanElyce OzolsPhyllis ChewDavid A VeseyGlenda C GobeChristudas MoraisRink-Jan LohmanJacky Y SuenDavid W JohnsonDavid P FairlieDavid J Nikolic Paterson

Published in: Nephrology (Carlton, Vic.) (2019)

Protease-activated receptor 2 expression is substantially up-regulated in tubular epithelial cells in the obstructed kidney, but this does not contribute to the development of tubular damage, renal inflammation or fibrosis.

Keyphrases

oxidative stress
high glucose
transcription factor
liver fibrosis
binding protein