Decreased cortical gyrification and surface area in the left medial parietal cortex in patients with treatment-resistant and ultratreatment-resistant schizophrenia.

Kazutoshi KitajimaShunsuke TamuraDaiki SasabayashiShinichiro NakajimaYusuke IwataFumihiko UenoYoshifumi TakaiJunichi TakahashiFernando CaravaggioWanna MarEdgardo Torres-CarmonaYoshihiro NodaPhilip GerretsenVincenzo de LucaMasaru MimuraShogo HiranoTomohiro Nakao Toshiaki OnitsukaGary RemingtonAriel Graff-GuerreroYoji Hirano

Published in: Psychiatry and clinical neurosciences (2022)

LGI and SA in the Lt-MPC, a functional hub in the default-mode network, were abnormally reduced in TRS compared with non-TRS. Thus, altered LGI and SA in the Lt-MPC might be structural features associated with genetic vulnerability to TRS.

Keyphrases

functional connectivity
bipolar disorder
resting state
climate change
network analysis
working memory
genome wide
gene expression
bioinformatics analysis