The two-dimensional material antimonene was first reported in 2015. Subsequently, its unique properties, including enhanced stability, high carrier mobility, and band-gap tunability, were predicted theoretically. These theoretical results have motivated experimental confirmation and thus a better understanding of this new material. Recently, the preparation of antimonene and its attempted use in several applications have attracted extensive attention. This Minireview focuses on both the experimental preparation and practical applications of antimonene, including the results of recent research on novel methods of preparing antimonene and its potential applications in optoelectronic devices, electrocatalysis, energy storage, and cancer therapy. Moreover, it provides insight that could further improve the preparation of antimonene and also describes numerous opportunities for application.