Novel murine xenograft model for the evaluation of stem cell therapy for profound dysphagia.

Maggie A KuhnAmanda B BlackM Tausif SiddiquiJan A NoltaPeter C Belafsky

Published in: The Laryngoscope (2017)

MDSCs exhibited over 100% survival at 3 months when injected into an immune-deficient hemiglossectomy mouse model. Tongue-injured animals injected with MDSCs exhibited superior weight gain after hemiglossectomy than control animals (P < .05). These data support further investigation into the use of autologous MDSCs as a potential treatment for dysphagia secondary to tongue weakness and fibrosis LEVEL OF EVIDENCE: NA Laryngoscope, 127:E359-E363, 2017.

Keyphrases

weight gain
stem cells
mouse model
body mass index
birth weight
bone marrow
weight loss
electronic health record
cell therapy
intellectual disability
physical activity
combination therapy
mesenchymal stem cells
climate change
free survival
risk assessment
machine learning
platelet rich plasma
smoking cessation