A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL-40/Interleukin-13 Receptor α2 Axis.
Yannick van SleenWilliam F JiemySarah PringleKornelis S M van der GeestWayel H AbdulahadMaria SandoviciElisabeth BrouwerPeter HeeringaAnnemieke M H BootsPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
In GCA, a GM-CSF-skewed, CD206+MMP-9+ macrophage subset expresses high levels of YKL-40 which may stimulate tissue destruction and angiogenesis through IL-13Rα2 signaling. Targeting YKL-40 or GM-CSF may inhibit macrophages that are currently insufficiently suppressed by glucocorticoids.