Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis.

Vicente MartínMarilena MelasAsaf Maoz Stephanie L Schmit Hedy S RennertFlavio LejbkowiczJoel K GreensonXavier SanjuanMaria Lopez-ZambranoMaria Henar AlonsoChenxu QuKevin J McDonnellGregory E IdosMarissa VignaliRyan EmersonPaul A FieldsElisabet GuinóCristina SantosRamon SalazarHarlan S RobinsGadi Rennert Stephen B Gruber Victor Moreno

Published in: PLoS medicine (2020)

Results from this study demonstrate that tumor lymphocytes, assessed by TCR repertoire quantification based on a sequencing method, are an independent prognostic factor in microsatellite stable stage II CRC.

Keyphrases

prognostic factors
regulatory t cells
single cell
genetic diversity
dendritic cells
high throughput sequencing