Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway.
Yohei ShimizuYasushi OgasawaraAtsuko MatsumotoTohru DairiPublished in: The Journal of antibiotics (2018)
We searched for specific inhibitors of the futalosine pathway, non-canonical pathway of menaquinone biosynthesis operating in Helicobacter pylori, from metabolites produced by actinomycetes. Aplasmomycin, a boron-containing macrodiolide, was isolated from Streptomyces sp. K15-0223 as a specific inhibitor of the futalosine pathway. We also showed boromycin, an analog of aplasmomycin, had similar activity.
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