Select Antitumor Cytotoxic CD8+ T Clonotypes Expand in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib.

Maria Joao BaptistaSivasubramanian BaskarErika M GaglioneKeyvan KeyvanfarInhye E AhnAdrian WiestnerClare Sun

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

In patients with CLL, established T-cell responses directed against tumor are suppressed by disease and reactivated by ibrutinib.See related commentary by Zent, p. 4465.

Keyphrases

chronic lymphocytic leukemia
nk cells
newly diagnosed
drug induced