Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization.

Jun Jie Piao Soomin Kim Dongho Shin Hwa Jong Lee Kyung-Hwa Jeon Wen Jie Tian Kyung Jae Hur Jong Soo Kang Hyun-Je Park Joo Young Cha Aeri Song Sang-Hyuck Park Mahadevan Raj Rajasekaran Woong Jin Bae Sungjoo Kim Yoon Sae Woong Kim

Published in: The world journal of men's health (2024)

CBD inhibits the TLR4/NF-κB pathway by activating the CB2 receptor, desensitizes the TRPV1 receptor, and decreases the release of COX2. This results in relief of inflammation and pain in patients with CP/CPPS, indicating CBD as a potential treatment for CP/CPPS.

Keyphrases

neuropathic pain
signaling pathway
oxidative stress
toll like receptor
nuclear factor
binding protein
pain management
cell proliferation
risk assessment
lps induced
spinal cord
pi k akt
spinal cord injury
combination therapy