Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove for Acinetobacter baumannii .
Theodoros KarampatakisKaterina TsergouliPayam BehzadiPublished in: Antibiotics (Basel, Switzerland) (2024)
Acinetobacter baumannii is a Gram-negative pathogen responsible for a variety of community- and hospital-acquired infections. It is recognized as a life-threatening pathogen among hospitalized individuals and, in particular, immunocompromised patients in many countries. A. baumannii, as a member of the ESKAPE group, encompasses high genomic plasticity and simultaneously is predisposed to receive and exchange the mobile genetic elements (MGEs) through horizontal genetic transfer (HGT). Indeed, A. baumannii is a treasure trove that contains a high number of virulence factors. In accordance with these unique pathogenic characteristics of A. baumannii , the authors aim to discuss the natural treasure trove of pan-genome and virulence factors pertaining to this bacterial monster and try to highlight the reasons why this bacterium is a great concern in the global public health system.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- pseudomonas aeruginosa
- gram negative
- drug resistant
- biofilm formation
- escherichia coli
- staphylococcus aureus
- cystic fibrosis
- genome wide
- healthcare
- end stage renal disease
- antimicrobial resistance
- copy number
- mental health
- ejection fraction
- chronic kidney disease
- prognostic factors
- newly diagnosed
- dna methylation
- peritoneal dialysis
- emergency department
- acute care
- patient reported outcomes
- intensive care unit
- respiratory failure