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Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation.

Xuesen LiVictor PhamMatthew TippinDongjun FuRaymond RendonLiankun SongEdward UchioBang H HoangXiaolin Zi
Published in: Cell communication and signaling : CCS (2019)
These findings provide a rationale for further investigating combination of FKB and Bortezomib for treatment of RB deficient, castration-resistant prostate cancer.
Keyphrases
  • prostate cancer
  • multiple myeloma
  • newly diagnosed
  • clinical trial
  • protein protein
  • small molecule
  • wild type