Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation.
Xuesen LiVictor PhamMatthew TippinDongjun FuRaymond RendonLiankun SongEdward UchioBang H HoangXiaolin ZiPublished in: Cell communication and signaling : CCS (2019)
These findings provide a rationale for further investigating combination of FKB and Bortezomib for treatment of RB deficient, castration-resistant prostate cancer.